Gautam Borthakur Selected Research

Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)

1/2024	A Phase 1/2 Study of Mini-Hyper-CVD plus Venetoclax in Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia.
12/2021	Venetoclax for Children and Adolescents with Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma.
1/2021	Phase 1 study to evaluate Crenigacestat (LY3039478) in combination with dexamethasone in patients with T-cell acute lymphoblastic leukemia and lymphoma.
1/2020	Clinical Experience With Venetoclax Combined With Chemotherapy for Relapsed or Refractory T-Cell Acute Lymphoblastic Leukemia.
1/2018	Hyper-CVAD plus nelarabine in newly diagnosed adult T-cell acute lymphoblastic leukemia and T-lymphoblastic lymphoma.
10/2017	TP53 mutation does not confer a poor outcome in adult patients with acute lymphoblastic leukemia who are treated with frontline hyper-CVAD-based regimens.
1/2016	Phase I study of evofosfamide, an investigational hypoxia-activated prodrug, in patients with advanced leukemia.
7/2015	Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia.
7/2015	A phase I study of danusertib (PHA-739358) in adult patients with accelerated or blastic phase chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant or intolerant to imatinib and/or other second generation c-ABL therapy.
6/2015	The association between opioid administration and response to therapy in patients with acute lymphoblastic leukemia.

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Gautam Borthakur Research Topics

Disease

172	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2024 - 09/2007
63	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 04/2024 - 06/2004
59	Neoplasms (Cancer) 03/2024 - 09/2007
56	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 03/2024 - 08/2007
42	Leukemia 02/2024 - 08/2008
17	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2024 - 05/2009
14	Philadelphia Chromosome 01/2022 - 06/2004
11	Acute Promyelocytic Leukemia 02/2024 - 01/2010
11	Hematologic Neoplasms (Hematological Malignancy) 01/2023 - 07/2008
11	Thrombocytopenia (Thrombopenia) 01/2023 - 09/2009
10	Primary Myelofibrosis (Myelosclerosis) 04/2024 - 08/2010
10	Nausea 11/2023 - 12/2010
10	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 12/2021 - 12/2007
10	Diarrhea 01/2021 - 01/2006
9	Anemia 04/2024 - 07/2010
9	Exanthema (Rash) 11/2023 - 07/2015
9	Blast Crisis (Blast Phase) 01/2023 - 05/2009
8	Infections 11/2023 - 05/2012
8	Chromosome Aberrations (Chromosome Abnormalities) 01/2023 - 03/2013
6	Disease Progression 05/2024 - 12/2010
6	Chronic Myelomonocytic Leukemia (Leukemia, Chronic Myelomonocytic) 03/2024 - 02/2007
6	Residual Neoplasm 01/2021 - 02/2016
5	Neutropenia 04/2024 - 09/2009
5	Hypoxia (Hypoxemia) 01/2023 - 01/2011
5	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2022 - 04/2016
5	Vomiting 01/2021 - 12/2010
5	Fatigue 01/2021 - 08/2010
5	Polycythemia Vera 04/2017 - 01/2004
4	Multiple Myeloma 01/2023 - 08/2011
4	Pleural Effusion (Pleural Effusions) 11/2022 - 01/2014
4	Hyperbilirubinemia 01/2022 - 10/2008
4	Myeloid Leukemia (Leukemia, Myelocytic) 01/2021 - 07/2012
4	Hypertension (High Blood Pressure) 12/2020 - 01/2011
4	Fibrosis (Cirrhosis) 10/2018 - 08/2010
4	Essential Thrombocythemia 01/2017 - 01/2004
3	Acute Kidney Injury (Acute Renal Failure) 12/2023 - 11/2015
3	Cytopenia 01/2021 - 09/2009
3	B-Cell Lymphoma (Lymphoma, B Cell) 01/2021 - 01/2019
3	Aplastic Anemia (Anemia, Hypoplastic) 11/2018 - 05/2012
3	Hemorrhage 03/2016 - 01/2004

Drug/Important Bio-Agent (IBA)

39	venetoclaxIBA 04/2024 - 03/2014
39	Cytarabine (Cytosar-U)FDA LinkGeneric 11/2023 - 09/2008
35	Tyrosine Kinase InhibitorsIBA 10/2023 - 05/2009
31	Imatinib Mesylate (Gleevec)FDA Link 11/2019 - 06/2004
24	Core Binding Factors (Core-Binding Factor)IBA 01/2024 - 12/2008
23	Azacitidine (5 Azacytidine)FDA Link 11/2023 - 04/2008
21	Decitabine FDA Link 01/2024 - 02/2007
17	Dasatinib (BMS 354825)FDA Link 04/2024 - 08/2008
16	Idarubicin (4 Demethoxydaunorubicin)FDA LinkGeneric 11/2023 - 10/2009
16	Proteins (Proteins, Gene)FDA Link 01/2023 - 12/2008
14	Clofarabine (Clolar)FDA Link 01/2021 - 09/2008
11	Sorafenib (BAY 43-9006)FDA Link 11/2023 - 04/2010
10	Phosphotransferases (Kinase)IBA 01/2023 - 09/2009
10	fludarabineIBA 01/2023 - 12/2007
10	fms-Like Tyrosine Kinase 3IBA 01/2023 - 01/2011
8	ruxolitinibIBA 11/2021 - 11/2011
7	ibrutinibIBA 01/2023 - 02/2016
7	Lenalidomide (CC 5013)FDA Link 01/2021 - 11/2009
7	nilotinib FDA Link 01/2020 - 08/2008
6	Arsenic Trioxide (Trisenox)FDA Link 02/2024 - 01/2017
6	Cladribine FDA LinkGeneric 11/2023 - 01/2014
6	Dexamethasone (Maxidex)FDA LinkGeneric 01/2021 - 02/2011
5	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 04/2024 - 08/2013
5	BilirubinIBA 11/2023 - 10/2014
5	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2023 - 12/2008
5	Gemtuzumab (Mylotarg)FDA Link 11/2022 - 10/2014
5	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 11/2020 - 01/2016
5	Transaminases (Aminotransferases)IBA 01/2020 - 10/2008
5	Hemoglobins (Hemoglobin)IBA 07/2018 - 06/2010
5	Vincristine (Oncovin)FDA LinkGeneric 02/2016 - 09/2010
4	Tretinoin (Retinoic Acid)FDA LinkGeneric 02/2024 - 01/2017
4	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 01/2023 - 02/2017
4	EnzymesIBA 01/2023 - 05/2012
4	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2023 - 03/2007
4	Cyclophosphamide (Cytoxan)FDA LinkGeneric 12/2021 - 06/2014
4	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA 01/2021 - 12/2012
4	InterferonsIBA 01/2021 - 09/2009
4	Histone Deacetylase InhibitorsIBA 12/2017 - 01/2012
3	NucleophosminIBA 01/2023 - 08/2013
3	NivolumabIBA 01/2023 - 09/2019
3	Lysine (L-Lysine)FDA Link 01/2023 - 01/2021
3	CreatinineIBA 01/2022 - 01/2010
3	trametinibIBA 01/2022 - 01/2016
3	Rituximab (Mabthera)FDA Link 12/2021 - 12/2010
3	eltrombopag FDA Link 11/2021 - 11/2018
3	LigandsIBA 11/2021 - 11/2016
3	bcr-abl Fusion ProteinsIBA 01/2020 - 06/2004
3	ponatinibIBA 12/2019 - 09/2015
3	Bortezomib (Velcade)FDA Link 07/2017 - 08/2011
3	peginterferon alfa-2a (Pegasys)FDA Link 04/2017 - 11/2009
3	ProdrugsIBA 01/2016 - 01/2011
3	obatoclaxIBA 12/2014 - 12/2008

Therapy/Procedure

129	Therapeutics 03/2024 - 01/2006
52	Drug Therapy (Chemotherapy) 05/2024 - 09/2007
7	Stem Cell Transplantation 01/2023 - 08/2010
7	Salvage Therapy 01/2021 - 10/2008
6	Induction Chemotherapy 01/2022 - 10/2009
5	Drug Tapering 11/2021 - 07/2010
4	Radiotherapy 01/2020 - 09/2007
3	Remission Induction 01/2021 - 12/2008